To date, 36 scientists have completed their novel research grants from the 7-year-old LRI -- an Institute investment of $9 million. A remarkable 61% of these investigators have now turned their innovative hypotheses into confirmed discoveries, winning $30 million in large-scale grants to advance new scientific approaches to how and why lupus occurs, and what can be done to prevent and treat it.

"The LRI has been the leader in seeking and funding unproven but promising scientific hypotheses in lupus," said Mark Shlomchik, MD, PhD, professor of Laboratory Medicine and Immunology at Yale University School of Medicine and a member of the LRI Scientific Advisory Board. "It's because the LRI supported these innovative ideas in the first place that successful competition for scarce federal funding was possible."

An estimated 1.5 million Americans, and millions more worldwide, have lupus. Many are young women in the prime of their lives. No one knows why lupus occurs, or how to prevent or cure it. There hasn't been a new treatment approved for lupus in nearly 50 years, and existing medications are often toxic and can have debilitating effects.

LRI Breakthrough Discoveries in Lupus

Since its inception 7 years ago, the Institute has invested $22 million overall in cutting-edge lupus research, and current LRI-supported investigators are poised to capture similar large-scale awards. The Institute supports scientists from wide-ranging specialties who might otherwise not receive funds for their innovative and untested hypotheses in lupus.

In a brief time, LRI scientists have made breakthrough discoveries in such diverse fields as genetics, molecular science, cardiovascular disease, kidney disease, cognitive science, biomarkers, and pathways to autoimmune attack. Discoveries include:

* 20 potential lupus biomarkers -- early predictors of disease and treatment effectiveness; six are now in clinical investigation and human testing.

* Genes that increase susceptibility to lupus

* Pathways that enable misguided antibodies to attack

* Molecules that determine control of the immune system

* Targets for new treatments

* Insights on how lupus damages organs -- the heart, kidneys, brain, skin

"I'm grateful to the LRI for being brave enough to fund unusual work at an early stage of development," said Philip Cohen, MD, of the University of Pennsylvania, who received an LRI research grant in 2001 and is continuing his investigations. "This initial funding was responsible for getting what is now a very large project off the ground."